Acan-IRES-CreERT2

모델명

C57BL/6Smoc-Acanem1(IRES-CreERT2)Smoc

카탈로그

NM-KI-200143

모델 상태

Repository Live

PDF 받기

유전자 요약

Official Symbol
Acan

Synonyms

Agc; cmd; Agc1; Cspg1; b2b183Clo

NCBI ID

11595

MGI ID

99602

Ensembl ID

ENSMUSG00000030607

Pubmed

Acan

Human Ortholog

ACAN

모델 설명

A IRES-CreERT2 expression cassette was knocked into the Acan gene stop codon site via CRISPR/Cas9 mediated recombination.
신청분야：Cre recombinase tool; When crossed with mice carrying a targeted floxed alleles, this strain is useful in eliminating tissue-specific conditional expression of the gene. These mice could be used to study degenerative cartilage diseases such as osteoarthritis and degenerative disc disease.

검증 데이터

image.png

Fig. 1 CreERT2-mediated recombination in the joints of AcanCreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the growth plate and articular cartilage of AcanCreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment.

image.png

Fig. 2 Detection of tdTomato(red) in various tissues of AcanCreERT2/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the growth plate and articular cartilage after tamoxifen treatment. Tdtomato expression can be also detected in individual cells derived from the brown fat, spleen, testis, skin, skeletal muscle and cardiac valves. Tdtomato expression can not be detected in the brain, thymus, retina, lung, liver, stomach, submandibular gland, kidney, pancreas, intestine, colon, skin and myocardium. (For more detailed information please contact our technical advisor.)


당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

조회
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

조회