Il17a-Cre

모델명

C57BL/6Smoc-Il17aem1(iCre-polyA(SV40))Smoc

카탈로그

NM-KI-200137

모델 상태

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유전자 요약

Official Symbol
IL17A

Synonyms

Il17; Ctla8; IL-17; Ctla-8; IL-17A

NCBI ID

16171

MGI ID

107364

Ensembl ID

ENSMUSG00000025929

Pubmed

IL17A

Human Ortholog

IL17A

모델 설명

A iCre-polyA expression cassette was knocked into the Il17a gene start codon site. This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying autoimmune inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis.
신청분야：Cre recombinase tool; T helper cell

검증 데이터

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Fig 1. Cre mediated recombination in lung of Il17aCre/+;Rosa26tdTomato/+ mouse. 

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Fig 2. Cre mediated recombination in mesenteric lymph nodes of Il17aCre/+;Rosa26tdTomato/+ mouse. 

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

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