Isl1-Cre

모델명

C57BL/6Smoc-Isl1em1(iCre-WPRE-pA)Smoc

카탈로그

NM-KI-200126

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Isl1

Synonyms

-

NCBI ID

16392

MGI ID

101791

Ensembl ID

ENSMUSG00000042258

Pubmed

Isl1

Human Ortholog

ISL1

모델 설명

A iCre-WPRE-pA expression cassette was knocked into the Isl1 gene start codon site.
신청분야：Cre recombinase tool; Isl1-Cre mice express Cre recombinase under the control of the ISL1 transcription factor. It can be used for lineage tracing of Isl1 positive cells.

검증 데이터

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Fig. 1 Cre-mediated recombination in the retina of IslCreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer (RGC) and inner nuclear layer (INL) of IslCre/+; Rosa26tdTomato/+ mouse.

image.png

Fig. 2 Cre-mediated recombination in the pancreas of IslCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the acinar cells and islet cells derived from IslCre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of IslCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the retina, pancreas, heart, brain, pituitary gland, lung, liver, stomach, submandibular gland, brown fat, kidney, intestine, colon, spleen, thymus, testis and epididymis. (For more detailed information please contact our technical advisor.)


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