Myf6-CreERT2

모델명

C57BL/6Smoc-Myf6em1(CreERT2-pA)Smoc

카탈로그

NM-KI-200125

모델 상태

Repository Live

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유전자 요약

Official Symbol
Myf6

Synonyms

MRF4; bHLHc4; herculin

NCBI ID

17878

MGI ID

97253

Ensembl ID

ENSMUSG00000035923

Pubmed

Myf6

Human Ortholog

MYF6

모델 설명

A CreERT2-pA expression cassette was knocked into the Myf6 gene start codon site. Myf6 (myogenic factor 6) is a DNA-binding protein involved in muscle development. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Myf6.
신청분야：Cre recombinase tool

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image.png

Fig. 1 CreERT2-mediated recombination in the muscle of Myf6CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the muscle of Myf6CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment.

myf6.png

Fig. 2 Detection of tdTomato(red) in various tissues of Myf6CreERT2/+; Rosa26tdTomato/+ mice. Tdtomato is expressed in the muscle and thymus after tamoxifen treatment. Tdtomato expression can not be observed in the brain, colon, epididymis, kidney, spleen, stomach, brown fat, intestine, heart, retina, liver, lung, pancreas, testis and salivary gland. (For more detailed information please contact our technical advisor.)

 


간행물

α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
References：Cell Research

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