Arc-CreERT2

모델명

C57BL/6Smoc-Arcem1(CreERT2-SV40-pA)Smoc

카탈로그

NM-KI-200101

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Arc

Synonyms

mArc; Arc3.1; C86064; arg3.1

NCBI ID

11838

MGI ID

88067

Ensembl ID

ENSMUSG00000022602

Pubmed

Arc

Human Ortholog

ARC

모델 설명

A CreERT2 expression cassette was knocked into the Arc gene start codon site.
신청분야：By mating the reporter mice with CreERT2-expressing mice, Arc positive cells derived from double-positive mice were permanently labeled by fluorescent protein after tamoxifen treatment. Arc, a immediate-early gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.

검증 데이터

Arc-CreERT2-1.png

Fig.1  Detection of tdTomato (red) in the  brain of ArcCreERT2/+; Rosa26tdTomato/+  mouse after tamoxifen treatment. CreERT2-mediated recombination in the brain can be induced by tamoxifen. Some leakiness were detected in the hippocampus and thalamus prior to tamoxifen exposure.

Arc-CreERT2-2.png

Fig. 2 Detection of tdTomato (red) in various tissues of ArcCreERT2/+; Rosa26tdTomato/+ mice. CreERT2-mediated recombination in the brain, liver, kidney, pancreas, lung, stomach, submandibular gland, skin, testis and epididymis, pituitary gland and eye can be induced by tamoxifen. Some leakiness were detected in the brain and brown fat prior to tamoxifen exposure. (For more detailed information please contact our technical advisor.)

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