Oxt-IRES-Cre

모델명

C57BL/6Smoc-Oxtem1(IRES-iCre)Smoc

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NM-KI-200090

모델 상태

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유전자 요약

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Oxt

모델 설명

A IRES-iCre expression cassette was knocked into the Oxt gene stop codon site.
신청분야:Cre recombinase tool; Oxt-IRES-Cre mice express Cre recombinase under the control of the endogenous oxytocin (Oxt) promoter. Cre recombinase is expressed in the brain. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in neurons expressing oxytocin.

검증 데이터

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Fig. 1 Cre-mediated recombination in the brain of OxtCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the olfactory bulb, cortex, thalamus and cerebellum derived from OxtCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the eyes of OxtCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal inner nuclear layer and ganglion cell layer derived from OxtCre/+; Rosa26tdTomato/+ mouse. 

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Fig. 3 Detection of tdTomato(red) in various tissues of OxtCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in some cells of the brain, retina, pituitary gland, heart, lung, liver, salivary gland, brown fat, kidney, pancreas, intestine, colon, spleen, ovary, skeletal muscle, skin and thymus. (For more detailed information please contact our technical advisor.)



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