Pdyn-IRES-Cre

모델명

C57BL/6Smoc-Pdynem1(IRES-iCre)Smoc

카탈로그

NM-KI-200089

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Pdyn

Synonyms

Dyn

NCBI ID

18610

MGI ID

97535

Ensembl ID

ENSMUSG00000027400

Pubmed

Pdyn

Human Ortholog

PDYN

모델 설명

A IRES-iCre expression cassette was knocked into the Pdyn gene stop codon site. Pdyn encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying depression, stress, anxiety, pain response, circadian rhythm and appetite control.
신청분야：Cre recombinase tool; Neuroscience

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Fig. 1 Cre-mediated recombination in the brain of PdynCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, hippocampus and striatum of PdynCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of  PdynCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in some cells of the brain, kidney, pancreas islet, heart, liver, lung, stomach, brown fat, intestine, colon, ovary, thymus and spleen. Tdtomato expression can not be observed in the salivary gland, skin or muscle. (For more detailed information please contact our technical advisor.)


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