Gja1-2A-DreERT2

모델명

C57BL/6Smoc-Gja1em1(2A-DreERT2）Smoc

카탈로그

NM-KI-200026

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Gja1

Synonyms

Cx43; Npm1; Cnx43; Gja-1; AU042049; AW546267; Cx43alpha1; connexin43

NCBI ID

14609

MGI ID

95713

Ensembl ID

ENSMUSG00000050953

Pubmed

Gja1

Human Ortholog

GJA1

모델 설명

A 2A-DreERT2 expression cassette was knocked into the Gja1 gene stop codon site via CRISPR/Cas9 mediated recombination.
신청분야：Dre recombinase tool

검증 데이터

image.png

Fig.1 DreERT2-mediated recombination in the adipose tissue of Gja1DreERT2/+；R26tdTomato/+ mouse. TdTomato (red) expression can be detected in the adipose tissue after tamoxifen treatment. Connexin 43 (Cx43, encoded by Gja1, green) is a cell-cell communication gap junction protein expressed in adipose tissue. (Documented in the following reference.)


간행물

A Suite of New Dre-recombinase Drivers Markedly Expands the Ability to Perform Intersectional Genetic Targeting
References：CELL STEM CELL

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

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