hMASP2
모델명
C57BL/6JSmo-Masp2tm1(hMASP2)/Smoc
카탈로그
NM-HU-2000076
모델 상태
Embryo cryopreservation
유전자 요약
Gene Symbol
Masp2
모델 설명
검증 데이터
Fig1. Detection of MASP2 expression in liver by RT-PCR.
Wild type: only one band at 479 bp with primers F1/R1(mMasp2);
Homozygous: only one band at 338 bp with primers F2/R2(hMASP2);
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig2. Detection of human MASP2 expression in Blood (A) and Liver (B) of WT C57BL/6 and HO hMASP2 mice by Western blot. (7 weeks old)
Abbr. HO, homozygous; WT, wild type.
Fig3. Detection of hMASP2 expression in liver in HO hMASP2 mice by IHC. (female, 13 weeks old)
Abbr. HO, homozygous; WT, wild type.
Fig4. Detection of hMASP2 expression in kidney in HO hMASP2 mice by IHC. (female, 13 weeks old)
Abbr. HO, homozygous; WT, wild type.
Fig5. Detection of IgA expression in liver in HO hMASP2 mice by IHC. (female, 13 weeks old)
Abbr. HO, homozygous; WT, wild type.
Fig6. Detection of IgA expression in kidney in HO hMASP2 mice by IHC. (female, 13 weeks old)
Abbr. HO, homozygous; WT, wild type.
Fig7. No obvious pathological features were found in liver in HO hMASP2 mice. (female, 13 weeks old)
Abbr. HO, homozygous; WT, wild type.
Fig8. No obvious pathological features were found in kidney in HO hMASP2 mice. (female, 13 weeks old)
Abbr. HO, homozygous; WT, wild type.
Fig9. Detection of mC3 expression in serum by ELISA. (female, 12 weeks old)
Abbr. HO, homozygous; WT, wild type.
Fig10. Lectin and alternative pathway activity of HO hMASP2 mice.
LP activity in serum of age-matched female (A) and male (B) wild-type C57BL/6 and HO hMASP2 mice at different dilutions (n=3/group); (C) AP activity in serum of age-matched male wild-type C57BL/6 and HO hMASP2 mice at different dilutions (n=3/group).
Fig11. LNP023 blocks alternative complement pathway activity in the serum of age-matched male wild-type C57BL/6 and HO hMASP2 mice (n=3/group).
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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