hCD3EDG/hEpCAM
모델명
C57BL/6JSmo-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Epcamtm1(hEPCAM)Smoc
카탈로그
NM-HU-220123
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Repository Live
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Table.1 Blood routine examination in male hCD3EDG/hEpCAM mice.
Table.2 Blood routine examination in female hCD3EDG/hEpCAM mice.
Fig.1 Detection of lymphcytes population in the (A) peripheral blood and (B) spleen of 8-week-old male and female homozygous hCD3EDG/hEpCAM dKI mice by FACS (n=3).
Fig.2 Pathological analysis of 8-week-old female hCD3EDG/hEpCAM dKI mice by H＆E staining.
There were no obvious pathological changes in these tissues.
Fig.3 Pathological analysis of 8-week-old male hCD3EDG/hEpCAM dKI mice by H＆E staining.
There were no obvious pathological changes in these tissues.
Fig.4 Detection of mouse EpCAM expression in 8-week-old wild-type mice (WT) by IHC with an anti-mouse EpCAM antibody.
The arrows indicate the positive mouse EpCAM staining (brown) in each tissue. (40x Magnification)
Fig.5 Detection of human EpCAM expression in 8-week-old wild-type mice (WT) and homozygous hCD3EDG/hEpCAM knockin mice by IHC with an anti-human EpCAM antibody.
The arrows indicate the positive EpCAM staining (brown) in each tissue. The results show that human EpCAM is highly expressed in the intestine and kidney of hCD3EDG/hEpCAM knockin mice. (40x Magnification)
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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