hC3
모델명
C57BL/6JSmo-C3tm1(hC3)/Smoc
카탈로그
NM-HU-2000079
모델 상태
Repository Live
유전자 요약
Gene Symbol
C3
모델 설명
검증 데이터
Fig1. Detection of C3 expression in liver by RT-PCR.
Wild type: only one band at 359 bp with primers F1/R1(mC3);
Heterozygous: one band at 359 bp with primers F1/R1(mC3) and one band at 357 bp with primers F2/R2(hC3);
Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig 2. Detection of heterozygous hC3 expression in serum by ELISA.
Abbr. Het, heterozygous; WT, wild type.
Note: Data from the collaborator.
Fig 3. Detection of hC3 expression in serum by ELISA(n=3).
Abbr. HO, homozygous; HE, heterozygous; WT, wild type.
Fig 4. Detection of hC3 expression in eyes in hom hC3 KI mice by IF (n=5/group).
Fig 5. The C3hu/hu mice showed inflammation in the portal region and bile duct hyperplasia (100× and 400×)
Fig 6. The C3hu/hu mice showed glomerular sclerosis, glomerular atrophy and inflammation of the capillary tufts area (100× and 400×)
Fig 7. Body Weight of C3hu/hu mouse (n=12/group).
Fig 8. Survival curve of C3hu/hu mouse (n=12/group).
Fig 9. Serum Biochemistry of C3hu/hu mouse (n=5/group).
Fig 10. Serum Biochemistry of C3hu/hu mouse (n=5/group, a different biochemical analyzer was used than in Fig 9).
Fig 11. Urinalysis of C3hu/hu mouse.
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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