hAPOE4
모델명
C57BL/6JSmo-Apoetm2(hAPOE4)Smoc
카탈로그
NM-HU-190002
모델 상태
Repository Live
유전자 요약
Gene Symbol
Apoe
모델 설명
검증 데이터
Fig1. Genotyping of WT 、KO & Humanized mice by PCR.
Primer P1/2 Wild type = 342 bp
Primer P3/4 mutant = 332 bp
M：100bp Plus DNA ladder.
Fig2. Detection of human APOE4 expression in Cerebellum in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig3. Detection of human APOE4 expression in Cornu ammonis 1(CA1) in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig4. Detection of human APOE4 expression in Cornu ammonis 3(CA3) in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig5. Detection of human APOE4 expression in Dentate Gyrus(DG) in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig6. Blood biochemical analysis of hAPOE4 mice (female, n=3).
Fig7. Detection of Aβ Expression in Brain Tissues of hAPOE Mice.
No specific Aβ(6E10)-positive signals were detected. As illustrated in representative images of cortex and hippocampus, 4x
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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