Il1b-Luc-2A-EGFP

모델명

C57BL/6Smoc-Il1bem1(Luc-eGFP)Smoc

카탈로그

NM-KI-00010

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
IL1B

Synonyms

Il-1b; IL-1beta

NCBI ID

16176

MGI ID

96543

Ensembl ID

ENSMUSG00000027398

Pubmed

IL1B

Human Ortholog

IL1B

모델 설명

A Luciferase-2A-EGFP-pA cassette was inserted at ATG site of mouse Il1b gene. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1b.
신청분야：Inflammation and immunity,gene tracing

검증 데이터

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IL1B-2.png

Fig1. IL1β reporter gene expression in the mice was monitored through noninvasive molecular imaging. IL1 β  in the mouse body was activated through LPS  treatment.

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Fig2. Analysis of EGFP expresssion in PBMC by FACS. The homozygous KI mouse expresses EGFP in  F4/80+ macrophages in peripheral blood.

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Fig3. Analysis of EGFP expresssion in the spleen by FACS. The homozygous KI mouse expresses EGFP in F4/80+ macrophages in the spleen.

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Fig4. Analysis of EGFP expresssion in the liver by FACS. The homozygous KI mouse expresses EGFP in F4/80+ macrophages in the liver.


간행물

Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: Evidence from humans and mice
References：ELSEVIER

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