hHER2
모델명
C57BL/6JSmo-Erbb2tm1(hERBB2)Smoc
카탈로그
NM-HU-200115
모델 상태
Repository Live
유전자 요약
Gene Symbol
Erbb2
모델 설명
검증 데이터
Fig1. Detection of HER2 expression by RT-PCR.
Wild type: only one band at 375 bp with primers F1/R1 (mHer2);
Homozygous: one band at 223 bp with primers F2/R2 (hHER2).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig2. Detection of HER2 expression in homozygous hHER2 mice by Western Blot.
Note: The HER2 antibody cross-reacted with mHER2 and humanized HER2.
Fig.3 Detection of Her2 expression in Colon of WT C57BL/6 and hHER2 mice by FACS. (In cooperation with the third party)
Fig.4 Detection of Her2 expression in Skin of WT C57BL/6 and hHER2 mice by FACS. (In cooperation with the third party)
Fig.5 Detection of Her2 expression in kideny of WT C57BL/6 and hHER2 mice by FACS. (In cooperation with the third party)
Fig.6 In vivo efficacy assessment of Herceptin in hHER2 mice bearing B16F10-HER2 syngeneic tumor.
Body weight (A) and Tumor volume (B) were measured of hHER2 mice.
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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