Ar-Flox

모델명

B6;129S-Artm1(flox)Smoc

카탈로그

NM-CKO-00110

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Ar

Synonyms

Tfm; AW320017

NCBI ID

11835

MGI ID

88064

Ensembl ID

ENSMUSG00000046532

Pubmed

Ar

Human Ortholog

AR

모델 설명

These mice carry loxP sites flanking exon 2 of Ar gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ar gene.

Disease Connection

Prostate Cancer

Phenotype(s)

MGI:5009703
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pten-Flox(NM-CKO-18004) and Pbsn-cre mice.

Reference(s)

Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, Plaisier S, Garraway IP, Huang J, Graeber TG, Wu H, Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth. Cancer Cell. 2011 Jun 14;19(6):792-804

Type 2 Diabetes Mellitus

Phenotype(s)

MGI:5502687
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Fabp4-cre mice.

Reference(s)

McInnes KJ, Smith LB, Hunger NI, Saunders PT, Andrew R, Walker BR, Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis. Diabetes. 2012 May;61(5):1072-81

Obesity

Phenotype(s)

MGI:2681522
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with CMV-cre mice.

Reference(s)

Matsumoto T, Takeyama K, Sato T, Kato S, Androgen receptor functions from reverse genetic models. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):95-9

간행물

Reproductive Deficits Induced by Prenatal Antimüllerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells
References：

Androgens drive sexual dimorphism in liver metastasis by promoting hepatic accumulation of neutrophils
References：Cell Reports

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