Mc4r-KO(2)

모델명

C57BL/6Smoc-Mc4rem1Smoc

카탈로그

NM-KO-205021

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Mc4r

Synonyms

Pkcp; Mc4-r

NCBI ID

17202

MGI ID

99457

Ensembl ID

ENSMUSG00000047259

Pubmed

Mc4r

Human Ortholog

MC4R

모델 설명

exon 1 of Mc4r gene was deleted to generate Mc4r knockout mice via CRISPR/Cas9 mediated recombination.

Disease Connection

Obesity

Phenotype(s)

MGI:3850836
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Mc3r-KO(NM-KO-190652) mice.

Reference(s)

Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY, Van Der Ploeg LH, Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet. 2000 Sep;26(1):97-102

Non-Alcoholic Steatohepatitis

Phenotype(s)

MGI:6405042

Reference(s)

Matsumoto M, Yashiro H, Ogino H, Aoyama K, Nambu T, Nakamura S, Nishida M, Wang X, Erion DM, Kaneko M, Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis. PLoS One. 2020;15(1):e0228212

Obesity

Phenotype(s)

MGI:3579026

Reference(s)

Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q , Berkemeier LR , Gu W , Kesterson RA , Boston BA , Cone RD , Smith FJ , Campfield LA , Burn P , Lee F, Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997 Jan 10;88(1):131-41

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

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