Mc3r-KO

모델명

C57BL/6Smoc-Mc3Rem1Smoc

카탈로그

NM-KO-190652

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Mc3r

Synonyms

MC3-R

NCBI ID

17201

MGI ID

96929

Ensembl ID

ENSMUSG00000038537

Pubmed

Mc3r

Human Ortholog

MC3R

모델 설명

Exon 1 of Mc3r gene was deleted to generate Mc3r knockout mice.
신청분야：obesity

Disease Connection

Obesity

Phenotype(s)

MGI:3850836
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Mc4r-KO(2)(NM-KO-205021) mice.

Reference(s)

Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY, Van Der Ploeg LH, Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet. 2000 Sep;26(1):97-102

obesity

Phenotype(s)

MGI:3639354

Reference(s)

Butler AA, Kesterson RA, Khong K, Cullen MJ, Pelleymounter MA, Dekoning J, Baetscher M, Cone RD, A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology. 2000 Sep;141(9):3518-21

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